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In recent years, HIV‐1 integrase (IN) has become an attractive target for designing antiretroviral agents. The first IN inhibitor approved for clinical use, raltegravir, has validated the pharmacological viability of IN inhibitors and signals the advent of a new generation of antiretroviral drugs. The development of raltegravir and other successful lead IN inhibitors has also influenced the IN inhibitor...
Histone deacetylases (HDACs) are enzymes that cleave off acetyl groups from acetyl‐lysine residues in histones and various nonhistone proteins. Four different classes of HDACs have been identified in humans so far. Although classes I, II, and IV are zinc‐dependent amidohydrolases, class III HDACs depend on nicotinamide adenine dinucleotide (NAD+) for their catalytic activity. According to their homology...
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